ESOMEP

Generic name: Esomeprazole
Manufacturer: ACI Ltd.

Esomep® is a preparation of Esomeprazole which is the S-isomer of Omeprazole, a proton pump inhibitor, weak base in nature and is concentrated and converted to the active form in the highly acidic environment of the intracellular canaliculi within the parietal cell, where it inhibits the enzyme H+/K+-ATPase, the acid pump. This effect on the final step of the gastric acid formation process is dosedependent and provides for highly effective inhibition of both basal and stimulated acid secretion, irrespective of the stimulus.


Indications
Esomep® is indicated for:

Treatment of gastroesophageal reflux disease (GERD)

- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Symptomatic treatment of gastroesophageal reflux disease (GERD)

Risk reduction of NSAID-associated gastric ulcer

- Healing of gastric ulcers associated with NSAID therapy
- Prevention of gastric and duodenal ulcers associated with NSAID

H. pylori eradication to reduce the risk of duodenal ulcer recurrence

- Healing of H. pylori associated duodenal ulcer
- Prevention of relapse of peptic ulcers in patient with H. pylori associated

Pathological hypersecretory conditions including Zollinger-Ellison Syndrome



Side effects
The most commonly reported side effects were nausea, vomiting, abdominal pain, flatulence, diarrhoea, constipation and headache. Less frequent side-effects include dry mouth, peripheral edema, dizziness, sleep disturbances, fatigue, paraesthesia, arthralgia, myalgia, rash, and pruritus.

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