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GABAPEN

Gabapen

Generic name: Gabapentin
Therapeutic Group: Drugs of Nervous System » Neuropathy Neuralgia
Manufacturer: Incepta Pharmaceuticals Ltd.

Gabapentin is an anti-convulsant drug. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of gabapentin are due to the activity of parent compound. It increases brain GABA levels , binds to alpha-2-delta subunit of voltage-gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acids . Food has no effect on the rate and extent of absorption of gabapentin and it is not appreciably metabolized in human. Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Elimination half-life is 5-7 hours and is unaltered by increased dose or following multiple dosing.

Indications
Neuralgia: (a) pain from diabetic neuropathy, (b) pos t herpetic neuralgia.

Partial seizures : Gabapentin is indicated as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.

Precautions
Patients should be instructed to take Gabapentin only as prescribed. While using Gabapentin patients should be instructed either not to drive a car or to operate other complex machinery until they have gained sufficient experiences about Gabapentin whether or not it affects their mental and/or motor performance adversely.

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