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Generic name: Omeprazole
Manufacturer: Eskayef Bangladesh Ltd.

Losectil capsule contains enteric-coated pellets of omeprazole. It is a specific inhibitor of the gastric proton pump (H+/K+-ATPase) in the parietal cell. There it produces dose - dependent inhibition of acid secretion by binding to the enzyme and effectively reduces gastric acid secretion. This effect leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. After oral administration, the onset of the antisecretory effect of Losectil occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.


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