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PANTEX

Generic name: Pantoprazole
Manufacturer: ACI Ltd.

Pantex® is a preparation of Pantoprazole. It is a substituted benzimidazole derivative that suppresses the proton pump, final step of gastric acid secretion, by forming a covalent bond to two sites of H+-K+ ATPase enzyme. This leads to inhibition of both basal and stimulated gastric acid secretion irrespective to the stimulus. The binding of Pantex® to the H+-K+ ATPase results antisecretory effect which persist longer than 24 hours.

Pantex® is indicated in the following indications:
- Peptic ulcer diseases
- Gastro esophageal reflux diseases
- Treatment of ulcer resistant to H2-receptor antagonist
- Treatment of ulcer induced by NSAIDs
- Gastro intestinal bleeding from stress or acid peptic diseases
- Eradication of Helicobacter pylori (in combination with antibiotics)
- Zollinger-Ellison syndrome
- Prophylaxis for acid aspiration syndrome during induction of anesthesia

Side Effects
No potentially life threatening side-effects or serious adverse reactions has been reported. In some few cases headache, diarrhea, abdominal pain, nausea, dizziness, epigastric discomfort, flatulence, skin rash, pruritis have been reported.

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