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PINOR

Pinor

Generic: Imipramine
Manufacture: Aristopharma Ltd.

Imipramine is the prototype of the tricyclic class of antidepressants. It is a potent inhibitor of norepinephrine reuptake at noradrenergic nerve endings. It is also an inhibitor of 5-hydroxytrytamine (5-HT) reuptake but these effects are less marked than those on norepinephrine. Imipramine is a competitive antagonist at alfa-adrenoceptors but the effects are relatively weak.

Indication:
Treatment of depression, management of panic disorder, management of pain, management of enuresis, treatment of hyperactivity and attention deficit.

Contraindications:
Recent myocardial infarction, arrhythmias (particularly heart block), not indicated in manic phase, severe liver disease.

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