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Tetrax

Generic Name: Tetracycline
Manufacturer: Square Pharmaceuticals Ltd.

Pharmacology

Tetracycline (Tetrax®) has its main mechanism of action on protein synthesis, and an energy-dependent active transport system pumps the drug through the inner cytoplasmic membrane of bacteria. Once inside the bacterial cell, tetracycline (Tetrax®) binds specifically to the 30s ribosomes and inhibit bacterial protein synthesis.

Tetracycline (Tetrax®) is the drug of choice in the following infections :

1. Ricketsial infection (Rocky Mountain spotted fever, endemic and scrub typhus fever and human ehrlichiosis).
2. Mycoplasma pneumoniae infections in adults. Outbreaks of pneumonia caused by this organism are common in barracks and institutions. Most cases occur in children and young adults. Maculopapular rashes, haemolytic anaemia and meningo-encephalitis occur rarely.
3. Chlamydial Infections - Chlamydia psittaci: This organism is the cause of psittacosis (ornithosis), a systemic illness contracted from infected birds. The pneumonia associated with it may be extensive, and severe systemic upset and death are common.Headache is a prominent early
symptom.
4. Non-gonococcal or non specific urethritis: Inflammation of the urethra not resulting from gonococcal, chlamydial, or other specific infectious
agents.
5. Lyme disease
6. Brucellosis
7. Miscellaneous infections, including granuloma inguinale, cholera, glanders, relapsing fever and V. vulnifians.

Other common uses of tetracycline (Tetrax®) include the following :
1. Urinary Tract Infections with susceptible organisms (including the acute urethral syndrome in women).
2. Bronchitis in patients with known underlying chronic lung diseases.
3. Pelvic inflammatory disease and other sexually transmitted diseases (STDs) regimen.
4. Travelers diarrhoea.
5. Acne vulgaris
6. Prostatitis.
7. As an alternative agent in the penicillin allergic patient with syphilis.
8. Anaerobic infections with susceptible organisms


USE IN PREGNANCY, LACTATION AND CHILDREN

Tetracycline should not be used during pregnancy because of the risk of hypertoxicity in the mother as well as the effects on the developing foetus. Use in pregnancy potentially during breast-feeding and in children up to the age of 8, or some authorise say 12 years, may result in impaired bone growth and permanent discoloration of the child's teeth.

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